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KMID : 0377619710200040357
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Korean Jungang Medical Journal
1971 Volume.20 No. 4 p.357 ~ p.359
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Investigation on the Biosynthetic Ability of Serum Haptoglobin by the Kidney
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Abstract
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It is believed that serum haptoglobin is mostly synthesized in the liver, since in severe hepatocelluar dysfunction the serum haptoglobin level is usually decreased. On the other hand, in various diseases including nephrosis the serum haptoglobin level is increased
very much. Therefore, there exists possibility that haptoglobin is also synthesized in the xtrahepatic tissues. The present experiment was undertaken to determine whether the kidney is also able to synthesize the serum haptoglobin or not.
Three cases of kidney transplantation which were performed at the St. Mary´s Hospital of the Catholic Medical College were examined. Both kidneys of the patients were removed in all cases. The genetic types of serum haptoglobin were determined by the Smithies starch gel electrophoresis and it was found that the genetic types of serum haptoglobin was not changed after kidney transplantation. Hence, it was certainly concluded that kidney does not participate in the synthesis of serum haptoglobin.
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KEYWORD
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